What does it mean if IGF-1 is high?

What does it mean if IGF-1 is high?

Elevated IGF-1 and GH may indicate acromegaly in adults. Increased levels of GH and IGF-1 are normal during puberty and pregnancy; during the latter, serum IGF-1 increases on average almost 2-fold. Otherwise, increased levels are most frequently due to pituitary tumors (usually benign).

Does testosterone raise IGF-1?

Testosterone significantly increased thymidine incorporation and the production of IGF-1 and IGF-BP (p < 0.05 vs control). However, T significantly decreased the cell surface binding of IGF-1 (p < 0.0001 vs control).

Which is better IGF or HGH?

HGH is generally considered to employ anti-insulin actions, whereas IGF-1 has insulin-like properties. By maintaining relatively low levels of IGF-1 and synergy between HGH and IGF-1 throughout your patients' adult life, they may be able to live a healthy lifestyle and experience optimal aging.

Does exercise increase growth factors?

Exercise is a robust physiological stimulator of the pituitary secretion of growth hormone (GH), and within approximately 15 min after the onset of exercise, plasma GH starts to increase.

Why is IGF-1 bad?

People may also misuse or abuse IGF-1. The side effects of IGF-1 may be similar to those of other growth hormones. These include overgrowth of body tissues, known as acromegaly, and damage to the joints, liver, and heart. IGF-1 can cause your blood glucose levels to drop.

How do you treat high IGF-1?

The oral medications cabergoline and bromocriptine (Parlodel) may help lower levels of GH and IGF-1 in some people. These drugs may also help decrease tumor size. To treat acromegaly, these medications usually need to be taken at high doses, which can increase the risk of side effects.

Does IGF-1 build muscle?

In addition to a direct anabolic effect on skeletal muscle—for example, the production of more protein—IGF-I is also capable of stimulating the proliferation and differentiation of muscle stem cells (satellite cells). Results of animal studies suggest that this process is obligatory for muscle hypertrophy to proceed.

Are IGF-1 supplements safe?

The U.S. Anti-Doping Agency warns that products that say they contain IGF-1 may not. It might also be diluted or the product could contain other potentially harmful substances. People may also misuse or abuse IGF-1. The side effects of IGF-1 may be similar to those of other growth hormones.

Does HGH shorten your life?

Other research has shown that people with low levels of HGH due to surgical or radiation damage to the pituitary gland that makes HGH have increased risk of cardiovascular disease, a factor that can shorten life span.

What stimulates IGF?

IGF-1 is produced primarily by the liver. Production is stimulated by growth hormone (GH). Most of IGF-1 is bound to one of 6 binding proteins (IGF-BP). IGFBP-1 is regulated by insulin.

What can I do to maintain my IGF 1 level?

• Use IGF-1 Supplements — IGF-1 supplements help to replenish your IGF-1 levels. Look for products that are made from pure deer antler velvet, as this natural material contains large amounts of IGF-1. Other things that will help maintain the IGF-1 levels in your body are reducing the amount of alcohol you consume and using a sauna regularly.

What is the effect of aerobic exercise on IGF-I?

• An interesting finding was that higher pretraining level of IGF-I was associated with greater decline in IGF-I with training. Insulin-sensitizing low-intensity aerobic exercise is thus considered to be an effective method for downregulating IGF-I and upregulating IGFBP-1 levels. 1. Introduction

How does IGF-1 affect the growth of bones?

• Typical teenagers illustrate the “growth” in insulin-like growth hormone as they consume massive amounts of food to satisfy their large appetites, which increases circulating IGF-1, commanding the bones to grow larger and longer.

How does exercise affect insulin like growth factor?

• Increased concentrations of circulating insulin-like growth factor-I (IGF-I) or IGF-I relative to IGF-binding proteins (IGFBPs) are associated with increased risk of developing several forms of cancer. Conversely, exercise is linked with reduced risk.